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국내 최대 기계·건설 공학연구정보
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  • Virtuous6D
  • 국내학술대회

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    국내학술대회 제목 게시판 내용
    제목(국문) 3D 바이오프린팅 기반 생체 이식형 정밀 약물 전달 시스템 개발
    제목(영문) The Development of Controlled Release System for Drug Delivery with 3D Bioprinting
    저자 명노현 (N. H. Myung ,울산과학기술원 ) ▷공저자네트워크등록하기
    강현욱 (K.H.Y ,울산과학기술대학교 생명공학 ) ▷공저자네트워크등록하기
    초록
    초록(영문)

    As the requirement for precision medicine increases, a development of controlled release drug delivery systems is
    becoming important. In the pharmaceutical industry, 3D bioprinting is useful manufacturing technique to fabricate a
    tailored-controlled drug release system based on digital control. This automated technique can produce the desired structure
    in microscale and use multiple printing materials. In this study, we propose a controllable and implantable drug release
    system. Capsule geometrical characteristics and material properties were evaluated to control the drug release.
    Furthermore, these parameters were used for simulation to estimate drug release profile in systems with various forms. The
    proposed system consists of biodegradable polymer, poly(ϵ -caprolactone) (PCL), and Pluronic F127 hydrogel. Thus, the
    implant of the developed system does not require additional removal surgery. Moreover, hydrogel matrix intrinsically has a
    large amount of water and can encapsulate therapeutic molecules which are suitable to deliver the encapsulated
    biomolecules such as proteins. The developed system is expected to be widely used for effective disease treatment, and
    mimic the biological pathway contained multiple proteins for tissue regeneration

    keyword Key words : 3D printing, Drug delivery system, Controlled release, Precision medicine
    저널명 한국정밀공학회 추계학술대회 ▷관련저널보기
    VOL 17
    PAGE 408
    발표년도 2017
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