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Due to the lack of donated human pancreas for diabetes cure, islet xenotransplantation has been studied for many years. The most important key is to maintain pancreatic islet function after implantation. The promising technique for this issue is encapsulation of pancreatic islet to protect them from the immune response. We developed a novel 3D structure to encapsulate pancreatic islet for xenotransplantation. This structure consists of three layers. First and third layer have pores for effective nutrients, oxygen translation and insulin secretion. Middle layer between first and third layer is room to store a large amount of pancreatic islet. To fabricate the 3D structure, projection based micro-stereolithography (pMSTL) system and bio-compatible/non bio-degradable photopolymer, ORMOCERs(microresist, Germany) were used. In the projection based micro-stereolithography system, a digital micro-mirror device was used for image generation. A 500-W mercury lamp, optical fiber and dielectric mirror were used for high-quality UV light. A 3-axis stage was also used for layer by layer fabrication. First, single-line fabrication experiment was performed to investigate the fabrication characteristics of the ORMOCERs. Based on single line fabrication experiment results, we fabricated 3D structure using ORMOCERs. This 3D structure will keep pancreatic islet from immune response.