As the requirement for precision medicine increases, a development of controlled release drug delivery systems is
becoming important. In the pharmaceutical industry, 3D bioprinting is useful manufacturing technique to fabricate a
tailored-controlled drug release system based on digital control. This automated technique can produce the desired structure
in microscale and use multiple printing materials. In this study, we propose a controllable and implantable drug release
system. Capsule geometrical characteristics and material properties were evaluated to control the drug release.
Furthermore, these parameters were used for simulation to estimate drug release profile in systems with various forms. The
proposed system consists of biodegradable polymer, poly(ϵ -caprolactone) (PCL), and Pluronic F127 hydrogel. Thus, the
implant of the developed system does not require additional removal surgery. Moreover, hydrogel matrix intrinsically has a
large amount of water and can encapsulate therapeutic molecules which are suitable to deliver the encapsulated
biomolecules such as proteins. The developed system is expected to be widely used for effective disease treatment, and
mimic the biological pathway contained multiple proteins for tissue regeneration