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A Magnetically Powered Stem Cell-Based Microrobot for Minimally Invasive Stem Cell Delivery via the Intranasal Pathway in a Mouse Brain
Sungwoong Jeon(Daegu Gyeongbuk Institute of Science and Technolog)
South Korea | Advanced Healthcare Materials
■  View full text
Advanced Healthcare Materials, Volume10, Issue19, October 6, 2021
https://onlinelibrary.wiley.com/doi/10.1002/adhm.202100801
  

■ Researchers
Sungwoong Jeon, Eunhee Kim, Jin-young Kim, Hongsoo Choi
Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), South Korea.
Sun Hwa Park, Sung Won Kim
Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary is Hospital, The Catholic University, Seoul


■ Abstract
Targeted stem cell delivery with microrobots has emerged as a potential alternative therapeutic strategy in regenerative medicine, and intranasal administration is an effective approach for minimally invasive delivery of therapeutic agents into the brain. In this study, a magnetically powered stem cell-based microrobot (Cellbot) is used for minimally invasive targeted stem cell delivery to the brain through the intranasal passage. The Cellbot is developed by internalizing superparamagnetic iron oxide nanoparticles (SPIONs) into human nasal turbinate stem cells. The SPIONs have no influence on hNTSC characteristics, including morphology, cell viability, and neuronal differentiation. The Cellbots are capable of proliferation and differentiation into neurons, neural precursor cells, and neurogliocytes. The Cellbots in the microfluidic channel can be reliably manipulated by an external magnetic field for orientation and position control. Using an ex vivo model based on brain organoids, it is determined that the Cellbots can be transplanted into brain tissue. Using a murine model, it is demonstrated that the Cellbots can be intranasally administered and magnetically guided to the target tissue in vivo. This approach has the potential to effectively treat central nervous system disorders in a minimally invasive manner.

 

  • Targeted stem cell delivery
  • microrobots
  • Cell-Based Microrobot
  • Minimally Invasive Stem Cell
  • Mouse Brain
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